Reichu: Indeed, the interplay between Ritsuko, Misato, Shinji, and EVA-01's eyes helps make this a very compositionally sound shot. The space is divided up in a very harmonious fashion, although I'm sure the virtual symmetry helps.
Gundampilotspaz: This part really illustrates the difference between Misato and Ritsuko. Misato is being far too emotional about the situation, whereas Ritsuko is being far too cold.
MDWigs: Also, here Misato refers to how long Rei took to synch with EVA-00. This, combined with other evidence we are given later, seems to indicate that she only became an “official” pilot and started testing in 2014.
felineki: Sho's exo-dentures look a bit more pointy than usual in this shot…