At the same time, her face is replaced with Shinji from the front.
The silhouette looks up.
Misato's silhouette fades out.
Sharp-kun: Misato's breasts seem larger than in the previous shot. Maybe it's just me.
Shin-seiki: I think Misato's posture in this cut may well be intended to anticipate this scene from #21.
Gundampilotspaz: Considering that she is always carring that pain with her, I think it is safe to assume that it has to do with her fathers death.
Reichu: Could be anticipating Kaji's death, as well.
Jinpun: I personally think that the OP portrays these ladies in the nude to show them as humans in their true form, stripped and almost innocent. Here, Misato looks rather lonely to me — but the one she looks up to see is none other than Shinji, who is a source of comfort for her.
As the show progresses, it is revealed that all the characters have problems getting close to other people. The nakedness of the female characters here could symbolize the breaking down of barriers (A.T. Fields) throughout the series.
thewayneiac: As I said in 004a, I think they are showing us what's in Shinji's mind; he thinks of the women in the show in a sexual context first.