Shin-seiki: I don't really believe that Misato could maintain her looks and figure while being the sort of serious alcoholic suggested by this scene. It's all just a bit over the top, so that we will (in retrospect) draw the connection between her loneliness and her drinking.
Incisivis: This shot always amuses me, for some reason. I think it's Shinji's expression.
OMF: I consider this our first real encounter with Shinji the Prude. Admittedly Misato's apartment is a disaster area, but his tone in previous cuts and his worried look here really gets his grave disapproval across. He's so put out by it that he'll actually go to the trouble of cleaning the entire apartment later on.
Reichu: (Go to the trouble of becoming Misato's live-in housekeeper, you mean.)
OMF: His excessive conservatism is another negative aspect of Shinji's character that drags him down constantly. It will be a constant, even self-destructive, source of friction between himself and Asuka later on.